GRAFTJACKET® Matrix is intended to be placed in chronic skin wounds in the feet of diabetic patients. GRAFTJACKET® Matrix is made from donated human skin, which undergoes a process that removes the epidermis and dermal cells. This process allows the body to accept the matrix and reduces the rejection response. The processing steps that yield the GRAFTJACKET® Matrix sufficiently preserve the human dermal tissue, including its native protein, collagen structure, blood vessel channels and essential biochemical composition, to allow cellular repopulation and revascularization through the body’s natural healing process.

GRAFTJACKET® Matrix is a three-dimensional scaffold that the body can use to build on. Think of it as the steel scaffolding of a new building. The three-dimensional structure provides the body an opportunity to rebuild the area of missing tissue.

After implantation, the body’s natural repair process revascularizes and repopulates the GRAFTJACKET® Matrix with cells and allows the body to convert the GRAFTJACKET® Matrix into living tissue, e.g., skin. This means that the body can use GRAFTJACKET® Matrix as it repairs itself.