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PRO-DENSE® Injectable Regenerative Graft has a unique triphasic resorption profile that provides an ideal environment for the direct deposition of bone by binding growth factors† and by providing a slowresorbing matrix that propagates healing across the defect. The regeneration of dense bone and the selfpropagating ability of the PRO-DENSE® graft may explain why the body is consistently laying down dense trabecular bone faster than autograft.*

All claims are based on a critically sized canine proximal humerus defect model. It is unknown how results from the canine model compare with clinical results in humans.

†Growth factor binding based on in vitro data of BMP-2 and VEGF. Data on file.

*FASTER THAN AUTOGRAFT: The accelerated rate of healing of the PRO-DENSE® treated defects compared to those treated with autograft is principally evident by the higher density bone (i.e., 170% average increase in area fraction of new bone compared to autograft at 13 weeks) and superior average mechanical properties at 13 weeks. DENSER THAN AUTOGRAFT: Histomorphometry reveals that the amount of newly regenerated bone of the PRO-DENSE® injectable treated defects at 13 weeks demonstrated a statistically significant 170% average increase in new bone formation versus defects treated with autograft. PRO-DENSE® injectable new bone area fraction is on average 170% denser than autograft at 13 weeks.