Case Studies
GRAFTJACKET® Regenerative Tissue Matrix - Ulcer Repair

Note: The GRAFTJACKET® Matrix is intended for the repair or replacement of damaged or inadequate integumental tissue. The GRAFTJACKET® Matrix provides a scaffold that allows the body to repair itself.

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A new human, acellular dermal matrix (GRAFTJACKET® Matrix) has been developed to aid the body in rapid closure of these difficult-to-heal wounds. GRAFTJACKET® Matrix offers soft tissue coverage, contains intact vascular channels and supports cellular revascularization and repopulation by host tissue. The patient is a 38 year-old female who initially presented with a 1-day-old ulcer over the sub left first metatarsal head. The patient has a history of uncontrolled diabetes with significant neuropathy, complications relating to an infection in her leg 5 years earlier, but an apparently intact vascular status.
Author: Howard Cox, DPM - Mercy Hospital, Iowa City, IA, Washington County Hospital, Washington, IA

The following cases demonstrate the effective use of the GRAFTJACKET® Matrix in three difficult chronic wounds. The sequential images demonstrate the repair over time, and importantly, provide a representative sample of what to expect at different time points. Secondary dressings included sterile mineral oil and were changed every 3 - 5 days, for the first 3 - 4 weeks. Standard off-loading was used in each case.
Authors: Stephen Brigido, DPM, Steven Boc, DPM - St. Agnes Medical Center, Philadelphia, PA | Douglas G. Stoker, DPM - LDS Hospital, Salt Lake City, UT

CASE ONE | 51 year-old male, non-insulin dependent
Deep (down-to-bone) chronic wound over the medial malleolus (rounded projection on the ankle) persistent for approximately 8 weeks. At 3 weeks, the depth had healed approximately 93% and the area had healed approximately 67%. At 6 weeks, the wound had completely healed.

CASE TWO | 33 year-old insulin dependent diabetic
Abscess due to blunt trauma. By 3 weeks the wound had closed approximately 90%. After 4 weeks, the wound had completely closed and the patient was able to return to weightlifting and cardiovascular exercise on a treadmill.

CASE THREE | 63 year-old male
Chronic ulcer persistent for approximately 6 months due to peripheral neuropathy with unknown etiology. At only 3 weeks, ulcer had healed approx. 80% of the depth and had closed to about 5mm. At 67 days, wound demonstrates epithelialization (the covering of a surface by the development of epithelial tissue, as in the healing of a wound) almost complete.