Physicians

Biologics

PRO-STIM® Injectable Inductive Graft

PRO-STIM® Injectable Inductive Graft is the next step in composite grafting technology. Built on the PRO-DENSE® material platform as a combination of calcium sulfate and calcium phosphate, PRO-STIM® graft adds demineralized bone matrix (DBM) for osteoinductive factors to speed the healing and remodeling process.

Pre-Clinical In-Vivo Testing

In an early timepoint study of PRO-STIM® graft and autograft materials in a critical sized defect, PRO-STIM® graft was associated with accelerated healing, earlier initiation of remodeling, and greater maximum bone volume during healing compared to autograft.*

Accelerated Healing versus Autograft

Amount (Area Fraction) of New Bone

Surgeon Observations

“PRO-STIM® graft gives the surgeon a viable alternative to autograft without the complications associated with the donor site. This option provides a proven, flowable, composite bone graft that adds DBM to enhance healing and remodeling into native bone. This setting material has been useful in my orthopaedic practice for both open and percutaneous applications such as bone cysts and core decompressions.”
- Michael D. Neel, MD, OrthoMemphis, Memphis, TN

*Canine proximal humerus model: Accelerated healing compared to autograft –Compared to autograft, PRO-STIM® Graft showed accelerated new bone formation at 13 and 26 weeks. This was evident by the slightly higher average stiffness, the greater amount of average new bone formation, and statistically significantly greater compressive strength shown for PRO-STIM® Graft treated defects. By comparing the 26-week clinical and contact radiographs and gross cross-sectional images and histological images, there appeared to be little to no apparent difference between defects filled with either PRO-STIM® Graft or autograft. Comparison of percentage of new bone, compressive strength, and modulus of elasticity showed no statistically significant differences between the materials at 26 weeks. Data on file at Wright. It is unknown how results from the canine model compare with clinical results in humans.