Bone graft substitute - PRO-DENSE® Injectable Regenerative Graft by Wright Medical

How it Works

Tri-Phasic Resorption Results in an Injectable, Self-forming, Porous Scaffold
In Vitro Accelerated Dissolution at 37°C in H₂O (Samples embedded and cross-sectioned for analysis via SEM)
(Approximately six times faster than in vivo canine model)

Time 0: Injectable graft sets up with a compressive strength of 40MPa (at 2 hours, wet conditions)

Time 4 days in an accelerated model (approx. 24 days in vivo): Calcium sulfate (CaSO₄) is resorbed primarily through simple dissolution in the 1st phase. The brushite and tricalcium phosphate (TCP) components remain forming an interconnected, porous scaffold.

Time 8 days in an accelerated model (approx. 48 days in vivo): Continued dissolution of the primary 1st phase. In vivo, the body will have begun osteoclastic resorption of the brushite (2nd phase) and TCP (3rd and final phase).

Time 12 days in an accelerated model (approx. 72 days in vivo): Further dissolution of the CaSO₄ and calcium phosphate (CaPO₄). During these later phases the body will lay down dense new bone on and throughout the porous scaffold.

CaSO₄ fully resorbed: The final phases of graft resorption will remove the remaining calcium phosphate. The body will remodel the regenerated bone to a more normal state over time.