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Pre-Clinical Findings:

Stronger, Faster, and More Dense Bone vs. Autograft.*

STRONGER THAN NORMAL BONE*: At 13 weeks; Urban, et al... CORR, June 2007.
*All claims are based on a critically sized canine proximal humerus defect model. It is unknown how results from the canine model compare with clinical results in humans.

Stronger New Bone*


Graph
Mechanical properties at 13 and 26 weeks: The PRO-DENSE® regenerate on average demonstrated over six times the compressive strength vs. autograft at 13 weeks, and over three times greater ultimate compressive strength than normal, unoperated bone.

*Data on file

Faster, Denser Bone Regeneration*


Autograft PRO-DENSE®
Histology at 13 weeks: The PRO-DENSE® specimen (right) demonstrated consistently denser and thicker trabeculae vs. autograft (left) at the same time point.
Basic Fuchsine and Toluidine Blue, 75x

* No 26 week data is available for Autograft.


PRO-DENSE® Graft

*All claims are based on a critically sized canine proximal humerus defect model. It is unknown how results from the canine model compare with clinical results in humans.

STRONGER THAN NORMAL BONE*: At 13 weeks; Urban, et al... CORR, June 2007.

FASTER THAN AUTOGRAFT*: The accelerated rate of healing of the PRO-DENSE® graft treated defects compared to those treated with autograft is principally evident by the higher density bone (i.e., 170% average increase in area fraction of new bone compared to autograft at 13 weeks) and superior average mechanical properties at 13 weeks.

DENSER THAN AUTOGRAFT*: Histomorphometry reveals that the amount of newly regenerated bone of the PRO-DENSE® injectable graft treated defects at 13 weeks demonstrated a statistically significant 170% average increase in new bone formation versus defects treated with autograft. PRO-DENSE® injectable graft new bone area fraction is on average 170% denser than autograft at 13 weeks.

STRONGER THAN AUTOGRAFT*: The newly regenerated bone in the PRO-DENSE® injectable graft treated defects exhibited a 645% average increase in compressive strength at 13 weeks versus defects treated with autograft.

 
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