Bone Graft Substitute
Dense, Direct Bone Deposition
PRO-DENSE® Bone Graft Substitute has a triphasic resorption profile that provides an ideal environment for the direct deposition of bone by binding growth factors† and by providing a slow re-sorbing matrix that supports healing across the defect.
The following illustrations describe the basic steps in the process of new bone formation.
Proposed Mechanism of Action
1. Angiogenesis is a key early event. The CaSO4 of the implant resorbs first, revealing a porous calcium phosphate scaffold conducive to vascular infiltration.
2. The resulting brushite/TCP scaffold with interconnecting pores binds free proteins such as VEGF and BMP-2 at the implant/defect interface.†
3. Resorption of the PRO-DENSE® scaffold releases bound proteins. Active proteins recruit cells to the implant surface.†
4. Growth factors in the implant/defect interface region, including BMPs, stimulate proliferation and differentiation of mesenchymal stem cells.
5. Differentiated osteoblasts lay down osteoid which then mineralizes to become newly woven bone.
6. The principles of Wolff’s Law drive remodeling.